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AttributesValues
rdf:type
rdfs:label
  • Afamelanotide
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Afamelanotide
UMLS_CUI
  • C2607750
CAS_Registry
  • 75921-69-6
FDA_UNII_Code
  • QW68W3J66U
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 636135
PDQ_Closed_Trial_Search_ID
  • 636135
Chemical_Formula
  • C78H111N21O19
Legacy_Concept_Name
  • Afamelanotide
FULL_SYN
  • Melanotan ISYNCI
  • Msh, 4-nle-7-phe-alpha-SYNCI
  • AFAMELANOTIDEPTFDAQW68W3J66U
  • AfamelanotidePTNCI
  • N-Acetyl-L-serinyl-L-tyrosyl-L-seryl-(2S)-2-aminohexanoyl-L-glutamyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophanylglycyl-L-lysyl-L-prolyl-L-valinamideSNNCI
  • CUV1647CNNCI
DEFINITION
  • A synthetic peptide analogue of the naturally occurring alpha-melanocyte stimulating hormone (a-MSH) with potential photoprotective activity. Mimicking the action of a-MSH, afamelanotide stimulates melanocytes to increase the production and release of melanin. Increased melanocyte melanin may protect against ultraviolet radiation (UVR)-initiated cellular DNA damage, oxidation of membrane proteins, and alterations in intracellular signaling processes in epidermal cells. Endogenously, a-MSH is released by skin cells in response to UVR exposure, stimulating melanocytes to produce and release melanin.NCI
code
  • C82655
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