About: Dimerizer AP1903     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Dimerizer AP1903
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Dimerizer AP1903
UMLS_CUI
  • C0965498
PDQ_Open_Trial_Search_ID
  • 640440
PDQ_Closed_Trial_Search_ID
  • 640440
Legacy_Concept_Name
  • Tacrolimus_Analogue_AP1903
FULL_SYN
  • Dimerizer AP1903PTNCI
  • AP1903CNNCI
DEFINITION
  • A lipid-permeable tacrolimus analogue with homodimerizing activity. Dimerizer drug AP1903 homodimerizes an analogue of human protein FKBP12 (Fv) which contains a single acid substitution (Phe36Val) so that AP1903 binds to wild-type FKBP12 with 1000-fold lower affinity. This agent is used to homodimerize the Fv-containing drug-binding domains of genetically engineered receptors such as the iCD40 receptor of the autologous dendritic cell vaccine BP-GMAX-CD1, resulting in receptor activation.NCI
code
  • C82412
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