About: Immunocytokine NHS-IL2-LT     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Immunocytokine NHS-IL2-LT
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Immunocytokine NHS-IL2-LT
NCI_META_CUI
  • CL408675
PDQ_Open_Trial_Search_ID
  • 641919
PDQ_Closed_Trial_Search_ID
  • 641919
Legacy_Concept_Name
  • Selectikine
FULL_SYN
  • Ch.14.18-IL2ABNCI
  • SelectikineFBNCI
  • Immunocytokine NHS-IL2-LTPTNCI
  • EMD 521873CNNCI
DEFINITION
  • A fusion protein consisting of a mouse-human chimeric antibody directed against DNA released by necrotic tumor cells fused to two molecules of a genetically modified human interleukin-2 (IL-2) with potential antineoplastic activity. Upon administration, the antibody moiety of immunocytokine NHS-IL2-LT binds to DNA released by necrotic tumor cells located primarily at the core of necrotic solid tumors, delivering the IL-2 moiety. In turn, the IL-2 moiety of this agent activates the immune system to mount a cytotoxic T lymphocyte response against nearby tumor cells.NCI
code
  • C82411
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