About: Erismodegib

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Erismodegib
rdfs:subClassOf	Signal Transduction Inhibitor
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance
Preferred_Name	Erismodegib
NCI_META_CUI	CL412311
CAS_Registry	956697-53-3
FDA_UNII_Code	0RLU3VTK5M
Contributing_Source	FDA
PDQ_Open_Trial_Search_ID	641974
PDQ_Closed_Trial_Search_ID	641974
Chemical_Formula	C26H26F3N3O3
Legacy_Concept_Name	Oral_Smoothened_Antagonist_LDE225
FULL_SYN	ErismodegibPTNCI Smoothened Antagonist LDE225SYNCI LDE225CNNCI LDE-225CNNCI ERISMODEGIBPTFDA0RLU3VTK5M
DEFINITION	An orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. Erismodegib selectively binds to the Hedgehog (Hh)-ligand cell surface receptor Smo, which may result in the suppression of the Hh signaling pathway and, so, the inhibition of tumor cells in which this pathway is abnormally activated. The Hh signaling pathway plays an important role in cellular growth, differentiation and repair. Inappropriate activation of Hh pathway signaling and uncontrolled cellular proliferation, as is observed in a variety of cancers, may be associated with mutations in the Hh-ligand cell surface receptor Smo.NCI
code	C82385

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