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AttributesValues
rdf:type
rdfs:label
  • Leucine-Enhanced Essential Amino Acid Dietary Supplement
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Leucine-Enhanced Essential Amino Acid Dietary Supplement
NCI_META_CUI
  • CL408637
PDQ_Open_Trial_Search_ID
  • 640231
PDQ_Closed_Trial_Search_ID
  • 640231
Legacy_Concept_Name
  • Leucine-Enhanced_Essential_Amino_Acid_Dietary_Supplement
FULL_SYN
  • Leucine-Enhanced Essential Amino Acid Dietary SupplementPTNCI
  • Leucine-Enhanced Essential Amino AcidsSYNCI
DEFINITION
  • An orally bioavailable leucine enriched essential amino acid dietary supplement with potential anti-cachexia activity. Leucine-enhanced essential amino acid nutritional supplement may stimulate the mammalian target of rapamycin (mTOR) signaling pathway, which may promote protein synthesis in muscle cells. Although the exact mechanism by which leucine and other essential amino acids stimulate mTOR has yet to be fully elucidated, leucine may stimulate mTOR by inhibiting adenosine monophosphate protein kinase (AMPK), which negatively controls mTOR signaling.NCI
code
  • C82357
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