About: Lutetium Lu 177-DOTA-di-HSG Peptide IMP-288     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Lutetium Lu 177-DOTA-di-HSG Peptide IMP-288
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Lutetium Lu 177-DOTA-di-HSG Peptide IMP-288
NCI_META_CUI
  • CL408635
PDQ_Open_Trial_Search_ID
  • 639752
PDQ_Closed_Trial_Search_ID
  • 639752
Legacy_Concept_Name
  • Lutetium_Lu_177-DOTA-di-HSG_Peptide_IMP-288
FULL_SYN
  • Lu-177-Labeled Di-Histamine-Succinyl-Glycine-DOTA Peptide IMP-288SYNCI
  • Lutetium Lu 177-DOTA-di-HSG Peptide IMP-288PTNCI
DEFINITION
  • A radiolabeled divalent histamine-succinyl-glycine (HSG) hapten-peptide linked with the macrocyclic chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) to the radionuclide lutetium (Lu) 177. After pretargeting with a bispecific monoclonal antibody (BiMoAB) directed against both a tumor associated antigen (TAA) and the HSG hapten-peptide, the HSG portion of administered Lu-177-labeled di-HSG-DOTA peptide IMP-288 binds the anti-HSG portion of the BiMoAB; Lu-177 radioisotopic activity localized to tumor cells bearing the TAA can then be visualized scintigraphically.NCI
code
  • C82354
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