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AttributesValues
rdf:type
rdfs:label
  • Sarmoxicillin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Sarmoxicillin
UMLS_CUI
  • C0614192
CAS_Registry
  • 67337-44-4
FDA_UNII_Code
  • R15K9Z4384
Contributing_Source
  • FDA
Chemical_Formula
  • C21H27N3O6S
Legacy_Concept_Name
  • Sarmoxicillin
FULL_SYN
  • SARMOXICILLINPTFDAR15K9Z4384
  • SarmoxicillinPTNCI
DEFINITION
  • An amoxicillin prodrug and the methoxymethyl ester of hetamoxicillin with antibacterial activity. Sarmoxicillin is hydrolyzed in vivo by esterases to its active metabolite amoxicillin. Amoxicillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall, eventually causing cell lysis.NCI
code
  • C82302
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