About: Alpha-1-Proteinase Inhibitor Human     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Alpha-1-Proteinase Inhibitor Human
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Alpha-1-Proteinase Inhibitor Human
UMLS_CUI
  • C0795657
CAS_Registry
  • 9041-92-3
FDA_UNII_Code
  • F43I396OIS
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 721983
PDQ_Closed_Trial_Search_ID
  • 721983
Legacy_Concept_Name
  • Alpha-1-Proteinase_Inhibitor_Human
FULL_SYN
  • Alpha-1-AntiproteinaseSYNCI
  • Prolastin-CBRNCI
  • Alpha-1-Proteinase Inhibitor HumanPTNCI
  • AATABNCI
  • A1ATABNCI
  • A1PIABNCI
  • AralastBRNCI
  • Alpha 1 AntitrypsinSYNCI
  • Alpha-1 AntitrypsinSYNCI
  • .ALPHA.1-PROTEINASE INHIBITOR HUMANPTFDAF43I396OIS
DEFINITION
  • Human serum-derived alpha-1 proteinase inhibitor (alpha-1-antitrypsin or AAT) with immunomodulating and anti-inflammatory activity. Upon administration, AAT reduces the production of proinflammatory cytokines, such as tumor necrosis factor-alpha, interleukin (IL)-1 beta, IL-32, IL-6, and proteinase 3, and induces the production of anti-inflammatory cytokines, such as IL-10 and the IL-1 receptor antagonist IL-1RN. This agent also downregulates heparan sulfate and reduces the expansion of cytotoxic effector T cells, interferes with the maturation of dendritic cells and increases T regulatory cells. Altogether, AAT may attenuate acute graft-versus-host disease (GvHD) and may facilitate graft acceptance and survival. In addition, AAT enhances levels of cAMP and activation of cAMP-dependent protein kinase A. AAT, a 52kD protein and serine protease inhibitor, belongs to the serpin superfamily.NCI
code
  • C82258
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