About: Telotristat Etiprate     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Telotristat Etiprate
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Telotristat Etiprate
NCI_META_CUI
  • CL407465
CAS_Registry
  • 1137608-69-5
Accepted_Therapeutic_Use_For
  • Carcinoid Syndrome, Ulcerative Colitis
FDA_UNII_Code
  • 3T25U84H4U
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 639514
  • 662188
PDQ_Closed_Trial_Search_ID
  • 639514
  • 662188
Chemical_Formula
  • C27H26ClF3N6O3.C9H9NO3
Legacy_Concept_Name
  • TPH_Inhibitor_LX1032
FULL_SYN
  • TELOTRISTAT ETIPRATEPTFDA3T25U84H4U
  • LX1032 HippurateCNNCI
  • LX1606 HippurateCNNCI
  • LX1606CNNCI
  • Tryptophan Hydroxylase Inhibitor LX1032SYNCI
  • Tryptophan Hydroxylase Inhibitor LX1606SYNCI
  • Ethyl 4-(2-amino-6-((1r)-1-(4-chloro-2-(3-methyl-1h-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pryrimidin-4-yl)-l-phenylalaninate N-benzoylglycinate (1:1)SNNCI
  • TPH Inhibitor LX1606SYNCI
  • Telotristat EtipratePTNCI
DEFINITION
  • An orally bioavailable, small-molecule, tryptophan hydroxylase (TPH) inhibitor prodrug, with potential antiserotonergic activity. Upon administration, telotristat etiprate is converted to its active moiety, telotristat (LP-778902), which binds to and blocks the activity of TPH. This may result in a reduction in peripheral serotonin (5-HT) production and improvement of serotonin-mediated gastrointestinal effects such as severe diarrhea. TPH, the rate-limiting enzyme in serotonin biosynthesis, is overexpressed in carcinoid tumor cells.NCI
code
  • C81941
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