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AttributesValues
rdf:type
rdfs:label
  • Tretazicar
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Tretazicar
UMLS_CUI
  • C0097964
CAS_Registry
  • 21919-05-1
FDA_UNII_Code
  • 7865D5D01M
Contributing_Source
  • FDA
Chemical_Formula
  • C9H8N4O5
Legacy_Concept_Name
  • Tretazicar
FULL_SYN
  • CB1954CNNCI
  • TRETAZICARPTFDA7865D5D01M
  • TretazicarPTNCI
DEFINITION
  • A prodrug of a bifunctional alkylating, dinitrobenzamide derivative with antineoplastic activity. Tretazicar can be activated by the human enzyme quinone oxidoreductase 2 (NQO2) in the presence of the cosubstrate caricotamide, an analogue of the natural cosubstrate dihydronicotinamide riboside (NRH), which acts as an electron donor. The resulting active, but short-lived metabolite, dinitrobenzamide, leads to DNA replication inhibition and the induction of apoptosis in NQO2 expressing cancer cells. Due to the lack of the natural cosubstrate NRH, NQO2 expression is normally latent but is upregulated in certain types of tumor cells.NCI
code
  • C81554
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