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AttributesValues
rdf:type
rdfs:label
  • Gadofosveset Trisodium
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Indicator, Reagent, or Diagnostic Aid
Preferred_Name
  • Gadofosveset Trisodium
UMLS_CUI
  • C1433439
CAS_Registry
  • 211570-55-7
FDA_UNII_Code
  • XM33Q67UVH
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 712739
PDQ_Closed_Trial_Search_ID
  • 712739
Chemical_Formula
  • C33H38N3O14P.Gd.3Na.H2O
Legacy_Concept_Name
  • Gadofosveset_Trisodium
FULL_SYN
  • Gadofosveset TrisodiumPTNCI
  • GADOFOSVESET TRISODIUMPTFDAXM33Q67UVH
  • MS-325CNNCI
  • AblavarBRNCI
  • VasovistBRNCI
DEFINITION
  • The trisodium salt form of gadofosveset, an injectable, intravascular, amphiphilic gadolinium-based contrast agent (GBCA) used with magnetic resonance angiography (MRA) imaging. Gadofosveset is a stable gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA) chelate derivative with a diphenylcyclohexylphosphate group. Upon injection, gadofosveset binds reversibly to endogenous serum albumin which increases its intravascular retention time compared to non-protein binding contrast agents. The serum albumin binding also increases T1-relaxivity of gadofosveset. This produces an increase in signal intensity of blood, thereby enhancing the visualization of blood vessels upon MRA and may aid in the diagnosis of certain blood vessels and heart disorders.NCI
code
  • C81057
is Has_Salt_Form of
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