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AttributesValues
rdf:type
rdfs:label
  • Flucloxacillin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Flucloxacillin
UMLS_CUI
  • C0016267
CAS_Registry
  • 5250-39-5
FDA_UNII_Code
  • 43B2M34G2V
Contributing_Source
  • FDA
Chemical_Formula
  • C19H17ClFN3O5S
Legacy_Concept_Name
  • Floxacillin
CHEBI_ID
  • CHEBI:5098
FULL_SYN
  • FloxacillinSYNCI
  • FLUCLOXACILLINPTFDA43B2M34G2V
  • FlucloxacillinPTNCI
  • 6-(3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolecarboxamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic AcidSNNCI
  • BRL 2039CNNCI
  • 3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolylpenicillinSNNCI
DEFINITION
  • A narrow-spectrum, semisynthetic isoxazolyl penicillin with antibacterial activity. Floxacillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall, eventually causing cell lysis.NCI
code
  • C80591
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