About: Retinoic Acid Agent

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Retinoic Acid Agent
rdfs:subClassOf	Differentiation Inducer
Semantic_Type	Classification
Preferred_Name	Retinoic Acid Agent
UMLS_CUI	C0035339
ALT_DEFINITION	A nutrient that the body needs in small amounts to function and stay healthy. Retinoic acid is made in the body from vitamin A and helps cells to grow and develop, especially in the embryo. A form of retinoic acid made in the laboratory is put on the skin to treat conditions such as acne and is taken by mouth to treat acute promyelocytic leukemia (a fast-growing cancer in which there are too many immature blood-forming cells in the blood and bone marrow). Retinoic acid is being studied in the prevention and treatment of other types of cancer.NCI-GLOSS
Legacy_Concept_Name	Retinoic_Acid_Agent
CHEBI_ID	CHEBI:26537
FULL_SYN	Retinoic AcidsSYNCI Retinoic Acid and DerivativesSYNCI Retinoic Acid AgentPTNCI retinoidPTNCI-GLOSSCDR0000045870 RetinoidSYNCI RetinoidsSYNCI
DEFINITION	A group of agents that includes retinol (Vitamin A) and related compounds with potential antineoplastic and/or chemopreventive activities. A retinoic acid agent binds to and/or activates specific nuclear retinoic acid receptors (RARs) and retinoid X receptors (RXRs), thereby modulating transcription of genes responsible for cell differentiation and proliferation. A retinoic acid agent may exhibit immunomodulatory and anti-inflammatory properties and may inhibit ornithine decarboxylase, resulting in a decrease in polyamine synthesis and keratinization. (NCI04)NCI
code	C804
is rdf:first of	nodeID://b737826
is rdfs:subClassOf of	VITAMIN A PALMITATE LGD 1550 TAZAROTENE Amsilarotene Mofarotene N-(4-Hydroxyphenyl)-9-cis-Retinamide N-(4-Ethoxyphenyl)Retinamide Temarotene Ro 16-9100 Tamibarotene Rexinoid NRX 194204 Retinoid Analogue NRX 195183 Retinoid 9cUAB30 Peretinoin Motretinide FENRETINIDE Carboxyphenyl Retinamide VITAMIN A ACETATE ALITRETINOIN BEXAROTENE Tretinoin Liposome ADAPALENE ETRETINATE Isotretinoin Fenretinide Lipid Matrix N-(2-Carboxyphenyl)Retinamide N-(Ethyl)-9-cis-Retinamide N-(4-Methoxyphenyl)retinamide Palovarotene Namirotene Etarotene Adarotene Acitretin

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