About: Granisetron Transdermal Patch     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Granisetron Transdermal Patch
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Granisetron Transdermal Patch
UMLS_CUI
  • C2370075
CAS_Registry
  • 109889-09-0
PDQ_Open_Trial_Search_ID
  • 642824
PDQ_Closed_Trial_Search_ID
  • 642824
Legacy_Concept_Name
  • Granisetron_Transdermal_Patch
FULL_SYN
  • 1-Methyl-N-(9-methyl-endo-9-azabicyclo(3.3.1)non-3-yl)-1H-indazole-3-carboxamideSNNCI
  • Granisetron Transdermal PatchPTNCI
  • SancusoBRNCI
  • Granisetron Transdermal SystemSYNCI
DEFINITION
  • A transdermal system containing granisetron, a selective serotonin (5-HT) receptor antagonist, with antiemetic activity. Upon application of the transdermal patch to the skin and subsequent release into the bloodstream, granisetron selectively binds to and blocks the 5-HT subtype 3 (5-HT3) receptors located in the vagus nerve terminal and in the vomiting center in the central nervous system (CNS). By preventing stimulation of 5-HT3 receptors, this agent is able to suppress chemotherapy-induced nausea and vomiting.NCI
code
  • C80377
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