About: Zoledronate Trisodium     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Zoledronate Trisodium
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Zoledronate Trisodium
UMLS_CUI
  • C2700333
CAS_Registry
  • 165800-08-8
FDA_UNII_Code
  • ARL915IH66
Contributing_Source
  • FDA
Legacy_Concept_Name
  • Zoledronate_Trisodium
FULL_SYN
  • ZOLEDRONATE TRISODIUMPTFDAARL915IH66
  • Phosphonic Acid, (1-hydroxy-2-(1H-imidazol-1-yl)ethylidene)bis-, Trisodium Salt Tetrahydrate (5:2)SNNCI
  • Trisodium Hydrogen (1-hydroxy-2-imidazol-1-ylethylidene)diphosphonate, Hydrate (5:2)SNNCI
  • CGP 42446BCNNCI
  • Zoledronate TrisodiumPTNCI
DEFINITION
  • The trisodium salt form of zoledronate, a synthetic imidazole, third generation bisphosphonate analog of pyrophosphate with antiresorptive activity. Zoledronate binds to hydroxyapatite crystals in the bone matrix and inhibits farnesyl pyrophosphate (diphosphate) synthase, thereby preventing protein prenylation within the mevalonate pathway. This leads to the loss of downstream metabolites essential for osteoclast function, leading to the induction of apoptosis and eventually, osteoclast-cell death. By preventing osteoclast-mediated bone resorption, zoledronate decreases bone turnover and stabilizes the bone matrix.NCI
code
  • C80325
is Has_Salt_Form of
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