About: Ioflubenzamide I-131     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Ioflubenzamide I-131
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Ioflubenzamide I-131
UMLS_CUI
  • C2934646
CAS_Registry
  • 1214283-52-9
FDA_UNII_Code
  • 65O1D58Z6V
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 615097
PDQ_Closed_Trial_Search_ID
  • 615097
Chemical_Formula
  • C21H25FIN3O3
Legacy_Concept_Name
  • Iodine_I_131_MIP-1145
FULL_SYN
  • N-(2-(diethylamino)ethyl)-4-((4-fluorobenzoyl)amino)-5-((sup 131)I)iodo-2-methoxybenzamideSYNCI
  • MIP-1145CNNCI
  • Ioflubenzamide I-131PTNCI
  • IOFLUBENZAMIDE I-131PTFDA65O1D58Z6V
DEFINITION
  • An iodine 131-radiolabeled small-molecule benzamide compound with potential antineoplastic activity. The benzamide moiety of 131-I-MIP-1145 binds to melanin, selectively delivering a cyotoxic dose of gamma and beta radiation to melanin-expressing tumor cells. Melanin pigments, polymer derivatives of the amino acid tyrosine, are over-expressed in approximately 40% of melanomas.NCI
code
  • C80056
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