About: CDK4 Inhibitor P1446A-05     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • CDK4 Inhibitor P1446A-05
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • CDK4 Inhibitor P1446A-05
NCI_META_CUI
  • CL388407
PDQ_Open_Trial_Search_ID
  • 618682
PDQ_Closed_Trial_Search_ID
  • 618682
Legacy_Concept_Name
  • CDK4_Serine_Threonine_Kinase_Inhibitor_P1446A-05
FULL_SYN
  • CDK4 Inhibitor P1446A-05PTNCI
  • P1446A-05CNNCI
DEFINITION
  • A protein kinase inhibitor specific for the cyclin-dependent kinase 4 (CDK4) with potential antineoplastic activity. CDK4 inhibitor P1446A-05 specifically inhibits CDK4-mediated G1-S phase transition, arresting cell cycling and inhibiting cancer cell growth. The serine/threonine kinase CDK4 is found in a complex with D-type G1 cyclins and is the first kinase to become activated upon mitogenic stimulation, releasing cells from a quiescent stage into the G1/S growth cycling stage; CDK-cyclin complexes have been shown to phosphorylate the retinoblastoma (Rb) transcription factor in early G1, displacing histone deacetylase (HDAC) and blocking transcriptional repression.NCI
code
  • C80049
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