About: 2'-F-ara-deoxyuridine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • 2'-F-ara-deoxyuridine
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name
  • 2'-F-ara-deoxyuridine
NCI_META_CUI
  • CL388502
CAS_Registry
  • 69123-94-0
FDA_UNII_Code
  • K7386OMP29
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of advanced solid tumors and lymphomas. It blocks the growth of cells and may cause cancer cells to die. It is a type of uracil analog.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 616102
PDQ_Closed_Trial_Search_ID
  • 616102
Chemical_Formula
  • C9H11FN2O5
Legacy_Concept_Name
  • _2-F-ara-deoxyuridine
FULL_SYN
  • 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl) UracilSNNCI
  • FAUPTNCI-GLOSSCDR0000642134
  • 1-(2-DEOXY-2-FLUORO-.BETA.-D-ARABINOFURANOSYL)URACILPTFDAK7386OMP29
  • FAUABNCI
  • 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl) uracilPTNCI-GLOSSCDR0000642135
  • 2'-F-ara-deoxyuridinePTNCI
DEFINITION
  • A deoxyuridine prodrug with potential antineoplastic activity. Upon cellular uptake, 2'-F-ara-deoxyuridine (FAU) is phosphorylated by thymidine kinase to FAU monophosphate and subsequently methylated in the 5'-position by thymidylate synthase (TS) to its activated form, 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) 5-methyluracil monophosphate (FMAUMP). FMAUMP is incorporated into DNA leading to an inhibition of DNA synthesis and so cell growth. The catalytic activity of TS is critical to activation of FAU and subsequent incorporation into DNA. FAU may be beneficial in the case of tumors with high TS activity that are resistant to TS inhibitors.NCI
code
  • C80036
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