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AttributesValues
rdf:type
rdfs:label
  • Caricotamide
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Caricotamide
PubMedID_Primary_Reference
  • 18062662
UMLS_CUI
  • C2699000
CAS_Registry
  • 64881-21-6
FDA_UNII_Code
  • MC09H30MFS
Contributing_Source
  • FDA
Chemical_Formula
  • C8H11N3O2
Legacy_Concept_Name
  • Caricotamide
FULL_SYN
  • CaricotamidePTNCI
  • 1-(2-Amino-2-oxoethyl)-1,4-dihydropyridine-3-carboxamideSNNCI
  • CARICOTAMIDEPTFDAMC09H30MFS
DEFINITION
  • A synthetic co-substrate that activates the human endogenous enzyme NRH:quinone oxidoreductase 2 (NQO2) with potential chemoadjuvant activity. When caricotamide is administered simultaneously with the prodrug tretazicar, NQO2 converts tretazicar to the bifunctional alkylating agent dinitrobenzamide, which is capable of forming a high degree of DNA interstrand cross-links, resulting in the inhibition of DNA replication and the induction of apoptosis. NQO2 has been found to be over-expressed in cancers such as hepatocellular carcinoma (HCC), colorectal and ovarian cancers.NCI
code
  • C79915
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