About: MEK-1/MEKK-1 Inhibitor E6201     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • MEK-1/MEKK-1 Inhibitor E6201
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • MEK-1/MEKK-1 Inhibitor E6201
NCI_META_CUI
  • CL388442
PDQ_Open_Trial_Search_ID
  • 629676
PDQ_Closed_Trial_Search_ID
  • 629676
Legacy_Concept_Name
  • MEK-1_MEKK-1_Tyrosine_Kinase_Inhibitor_E6201
FULL_SYN
  • MEK-1/MEKK-1 Inhibitor E6201PTNCI
  • E6201CNNCI
DEFINITION
  • A synthetic, fungal metabolite analogue inhibitor of mitogen-activated protein kinase kinase 1 (MEK-1) and mitogen-activated protein kinase kinase kinase 1 (MEKK-1) with potential antipsoriatic and antineoplastic activities. MEK-1/MEKK-1 inhibitor E6201 specifically binds to and inhibits the activities of MEK-1 and MEKK-1, which may result in the inhibition of tumor cell proliferation. MEK-1 and MEKK-1 are key components in the RAS/RAF/MEK/MAPK signaling pathway, which regulates cell proliferation and is frequently activated in human cancers.NCI
code
  • C79848
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