About: Masitinib Mesylate     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Masitinib Mesylate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Masitinib Mesylate
UMLS_CUI
  • C2351399
PDQ_Open_Trial_Search_ID
  • 629109
PDQ_Closed_Trial_Search_ID
  • 629109
Legacy_Concept_Name
  • Masitinib_Mesylate
FULL_SYN
  • AB1010CNNCI
  • Masitinib MesylatePTNCI
  • 4-[(4-Methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[4-(pyridin-3-yl)-1,3-thiazol-2-yl]amino}phenyl)benzamide MesylateSNNCI
DEFINITION
  • The orally bioavailable mesylate salt of masatinib, a multi-targeted protein tyrosine kinase inhibitor with potential antineoplastic activity. Masitinib selectively binds to and inhibits both the wild-type and mutated forms of the stem cell factor receptor (c-Kit; SCFR); platelet-derived growth factor receptor (PDGFR); fibroblast growth factor receptor 3 (FGFR3); and, to a lesser extent, focal adhesion kinase (FAK). As a consequence, tumor cell proliferation may be inhibited in cancer cell types that overexpress these receptor tyrosine kinases (RTKs).NCI
code
  • C79831
is Has_Salt_Form of
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