About: Cixutumumab     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Cixutumumab
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Immunologic Factor
Preferred_Name
  • Cixutumumab
UMLS_CUI
  • C2703174
CAS_Registry
  • 947687-12-9
FDA_UNII_Code
  • 2285XW22DR
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of some types of cancer. It is a monoclonal antibody that is made in the laboratory and can bind to substances in the body. Cixutumumab blocks the action of a protein needed for cell growth and may kill cancer cells. It is a type of insulin-like growth factor-1 receptor (IGF-1R) inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 561575
PDQ_Closed_Trial_Search_ID
  • 561575
Legacy_Concept_Name
  • Cixutumumab
FULL_SYN
  • CixutumumabPTNCI
  • cixutumumabPTNCI-GLOSSCDR0000644304
  • IMC-A12PTNCI-GLOSSCDR0000644305
  • IMC-A12CNNCI
  • Anti-IGF-1R Recombinant Monoclonal Antibody IMC-A12SYNCI
  • CIXUTUMUMABPTFDA2285XW22DR
DEFINITION
  • A fully human IgG1 monoclonal antibody directed against the human insulin-like growth factor-1 receptor (IGF-1R) with potential antineoplastic activity. Cixutumumab selectively binds to membrane-bound IGF-1R, thereby preventing the binding of the natural ligand IGF-1 and the subsequent activation of PI3K/AKT signaling pathway. Downregulation of the PI3K/AKT survival pathway may result in the induction of cancer cell apoptosis and may decrease cancer cellular proliferation. IGF-1R, a receptor tyrosine kinase of the insulin receptor superfamily overexpressed by many cancer cell types, stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis; IGF-1R signaling has been implicated in tumorigenesis and metastasis.NCI
code
  • C79828
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