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AttributesValues
rdf:type
rdfs:label
  • Quinidine
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Quinidine
UMLS_CUI
  • C0034414
CAS_Registry
  • 56-54-2
FDA_UNII_Code
  • ITX08688JL
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 39022
PDQ_Closed_Trial_Search_ID
  • 39022
Chemical_Formula
  • C20H24N2O2
Legacy_Concept_Name
  • Quinidine
CHEBI_ID
  • CHEBI:28593
FULL_SYN
  • QUINIDINEPTFDAITX08688JL
  • QUINIDINESYDTPNSC0010004
  • QuinidinePTNCI
DEFINITION
  • An alkaloid extracted from the bark of the Cinchona tree with class 1A antiarrhythmic and antimalarial effects. Quinidine stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thereby inhibiting the sodium influx required for the initiation and conduction of impulses resulting in an increase of the threshold for excitation and decreased depolarization during phase 0 of the action potential. In addition, the effective refractory period (ERP), action potential duration (APD), and ERP/APD ratios are increased, resulting in decreased conduction velocity of nerve impulses. Quinidine exerts its antimalarial activity by acting primarily as an intra-erythrocytic schizonticide through association with the heme polymer (hemazoin) in the acidic food vacuole of the parasite thereby preventing further polymerization by heme polymerase enzyme. This results in accumulation of toxic heme and death of the parasite.NCI
code
  • C793
is someValuesFrom of
is Has_Free_Acid_Or_Base_Form of
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