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AttributesValues
rdf:type
rdfs:label
  • Tetrodotoxin
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Tetrodotoxin
UMLS_CUI
  • C0039705
PDQ_Open_Trial_Search_ID
  • 611933
PDQ_Closed_Trial_Search_ID
  • 611933
Legacy_Concept_Name
  • Tetrodotoxin
CHEBI_ID
  • CHEBI:9506
FULL_SYN
  • TetrodotoxinPTNCI
  • TTXSYNCI
  • TectinBRNCI
DEFINITION
  • A neurotoxin with potential analgesic activity. Tetrodotoxin binds to the pores of fast voltage-gated fast sodium channels in nerve cell membranes, inhibiting nerve action potentials and blocking nerve transmission. Although found in various species of fish (such as the pufferfish), newts, frogs, flatworms, and crabs, tetrodotoxin, for which there is no known antidote, is actually produced by bacteria such as Vibrio alginolyticus, Pseudoalteromonas tetraodonis, and other vibrio and pseudomonas bacterial species.NCI
code
  • C78845
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