About: Anti-Myeloma Monoclonal Antibody-DM4 Immunoconjugate BT-062     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Anti-Myeloma Monoclonal Antibody-DM4 Immunoconjugate BT-062
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Anti-Myeloma Monoclonal Antibody-DM4 Immunoconjugate BT-062
NCI_META_CUI
  • CL387726
PDQ_Open_Trial_Search_ID
  • 609930
PDQ_Closed_Trial_Search_ID
  • 609930
Legacy_Concept_Name
  • Maytansinoid-Conjugated_Anti-Myeloma_Monoclonal_Antibody_BT062
FULL_SYN
  • Maytansinoid-Conjugated Anti-Myeloma Monoclonal Antibody BT062SYNCI
  • BT-062CNNCI
  • Anti-Myeloma Monoclonal Antibody-DM4 Immunoconjugate BT-062PTNCI
DEFINITION
  • An immunoconjugate consisting of a monoclonal antibody directed against a highly-expressed myeloma cell surface antigen covalently attached to the maytansinoid DM4, a derivative of the cytotoxic agent maytansine (DM1), with potential antineoplastic activity. Anti-myeloma cell surface antigen immunoconjugate BT-062 binds to an unspecified cell surface antigen highly expressed on myeloma cells; upon internalization the DM4 moiety is released, binding to tubulin and disrupting microtubule assembly/disassembly dynamics, which may result in the inhibition of cell division and cell growth of myeloma tumor cells.NCI
code
  • C78840
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