About: DS Stage III Plasma Cell Myeloma     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • DS Stage III Plasma Cell Myeloma
equivalentClass
Semantic_Type
  • Neoplastic Process
Preferred_Name
  • DS Stage III Plasma Cell Myeloma
UMLS_CUI
  • C0278724
ALT_DEFINITION
  • A relatively large number of cancer cells have spread throughout the body. There may be one or more of the following: 1) a decrease in the number of red blood cells, causing anemia; 2) the amount of calcium in the blood is very high, because the bones are being damaged; 3) more than three bone tumors (plasmacytomas) are found; or 4) high levels of M protein are found in the blood or urine.NCI-GLOSS
Neoplastic_Status
  • Malignant
Legacy_Concept_Name
  • Stage_III_Multiple_Myeloma
FULL_SYN
  • Stage III Multiple MyelomaSYNCI
  • Multiple Myeloma Stage IIISYNCI
  • Stage III Plasma Cell MyelomaSYNCI
  • stage III multiple myelomaPTNCI-GLOSSCDR0000044866
  • DS Stage III Multiple MyelomaSYNCI
  • Durie/Salmon Stage III Multiple MyelomaSYNCI
  • DS Stage III Plasma Cell MyelomaPTNCI
  • Durie/Salmon Stage III Plasma Cell MyelomaSYNCI
DEFINITION
  • Plasma cell myeloma with one or more of the following: 1. Hemoglobin less than 8.5 g/dL. 2. Serum calcium greater than 12.0 mg/dL. 3. More than three lytic bone lesions. 4. High M protein production as shown by: a. IgG greater than 7.0 g/dL. b. IgA greater than 5.0 g/dL. c. Urinary kappa or lamda greater than 12.0 g/24 hours. Estimated myeloma cell mass: greater than 1.2 trillion (1012)/m2 (high burden). The following subclassification of stages is used: a. Creatinine less than 2.0 mg/dL. b. Creatinine greater than or equal to 2.0 mg/dL. Serum beta-2-microglobulin has been shown to be a reliable marker for prognosis. Since the great majority of symptomatic myeloma patients are classified as stage III by the Durie/Salmon criteria, this staging system has not proven to be very useful for identifying the patients with intermediate and poor prognosis. Note that the newer International Staging System defines stage III quite differently: Beta-2-microglobulin greater than or equal to 5.5 (median survival of 29 months). (PDQ)NCI
code
  • C7852
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