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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • White Button Mushroom Extract
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • White Button Mushroom Extract
NCI_META_CUI
  • CL387508
PDQ_Open_Trial_Search_ID
  • 599759
PDQ_Closed_Trial_Search_ID
  • 599759
Legacy_Concept_Name
  • White_Button_Mushroom_Extract
FULL_SYN
  • WBM ExtractABNCI
  • White Button Mushroom ExtractPTNCI
DEFINITION
  • A heat-stable extract of white button mushrooms (Agaricus bisporus) with potential chemopreventive and immunomodulating activities. Phytochemicals, such as polysaccharides and especially beta-D-glucans found in the white button mushroom extract, bind to and inhibit the activity of aromatase, an enzyme responsible for the conversion of androgens to estrogens and which is often upregulated in breast cancer cells. The consequent decrease in estrogen production may result in the suppression of estrogen-dependent cellular proliferation. In addition, this extract may promote dendritic cell (DC) maturation, increase interferon gamma (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha) production, and may enhance natural killer (NK) cell activity, thus amplifying both innate and T cell-mediated immune responses against cancer cells.NCI
code
  • C78490
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