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AttributesValues
rdf:type
rdfs:label
  • Padeliporfin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Padeliporfin
NCI_META_CUI
  • CL387568
CAS_Registry
  • 759457-82-4
FDA_UNII_Code
  • EEO29FZT86
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 600817
PDQ_Closed_Trial_Search_ID
  • 600817
Chemical_Formula
  • C37H43N5O9S.Pd
Legacy_Concept_Name
  • Palladium-Bacteriochlorophyll_Derivative_WST11
FULL_SYN
  • PADELIPORFINPTFDAEEO29FZT86
  • PadeliporfinPTNCI
  • Palladium-Bacteriochlorophyll Derivative WST11SYNCI
  • WST11CNNCI
DEFINITION
  • A vascular-acting photosensitizer consisting of a water-soluble, palladium-substituted bacteriochlorophyll derivative with potential antineoplastic activity. Upon administration, paldeliporfin is activated locally when the tumor bed is exposed to low-power laser light; reactive oxygen species (ROS) are formed upon activation and ROS-mediated necrosis may occur at the site of interaction between the photosensitizer, light and oxygen. Vascular-targeted photodynamic therapy (VTP) with padeliporfin may allow tumor-site specific cytotoxicity while sparing adjacent normal tissues.NCI
code
  • C78481
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