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AttributesValues
rdf:type
rdfs:label
  • Topical Betulinic Acid
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Topical Betulinic Acid
NCI_META_CUI
  • CL387585
PDQ_Open_Trial_Search_ID
  • 600544
PDQ_Closed_Trial_Search_ID
  • 600544
Legacy_Concept_Name
  • Topical_Betulinic_Acid
FULL_SYN
  • Topical Betulinic AcidPTNCI
  • Topical ALS-357CNNCI
DEFINITION
  • A topical formulation of a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) with antiinflammatory, anti-HIV and antineoplastic activities. Betulinic acid induces apoptosis through induction of changes in mitochondrial membrane potential, production of reactive oxygen species, and opening of mitochondrial permeability transition pores, resulting in the release of mitochondrial factors involved in apoptosis, activation of caspases, and DNA fragmentation. Although originally thought to exhibit specific cytotoxicity against melanoma cells, this agent has been found to be cytotoxic against non-melanoma tumor cell types including neuroectodermal and brain tumor cells.NCI
code
  • C78477
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