About: Topical Myristyl Nicotinate Cream     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Topical Myristyl Nicotinate Cream
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Topical Myristyl Nicotinate Cream
NCI_META_CUI
  • CL387586
ALT_DEFINITION
  • A substance being studied in the prevention of skin cancer. Myristyl nicotinate cream is also being studied as a way to help lessen the side effects of retinoic acid (a form of vitamin A) when it is used to treat skin that has been damaged by the sun. Myristyl nicotinate cream contains a form of niacin (a member of the vitamin B complex). It is a type of chemopreventive agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 599997
PDQ_Closed_Trial_Search_ID
  • 599997
Legacy_Concept_Name
  • Topical_Myristyl_Nicotinate_Cream
FULL_SYN
  • Topical Myristyl Nicotinate CreamPTNCI
  • myristyl nicotinate creamPTNCI-GLOSSCDR0000626298
DEFINITION
  • A topical cream containing the ester prodrug myristyl nicotinate (MN), a lipophilic nicotinic acid derivative with potential chemopreventive activity. Upon topical application, myristyl nicotinate penetrates into the epidermis where the agent is cleaved and is converted into nicotinic acid (niacin); nicotinic acid then diffuses into cells where it is converted to nicotinamide adenine dinucleotide (NAD). NAD may stimulate poly(ADP-ribose) polymerase-1 (PARP-1); enhance skin cell turnover and epidermal differentiation; and strengthen skin barrier function. NAD is a coenzyme that plays a crucial role in many redox reactions; PARP-1 is an enzyme that plays an important role in DNA repair.NCI
code
  • C78469
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