About: Fluorine F-18 ML-10     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Fluorine F-18 ML-10
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
  • Indicator, Reagent, or Diagnostic Aid
Preferred_Name
  • Fluorine F-18 ML-10
NCI_META_CUI
  • CL387589
PDQ_Open_Trial_Search_ID
  • 599996
PDQ_Closed_Trial_Search_ID
  • 599996
Legacy_Concept_Name
  • _18F_2_5-Fluoro-Pentyl_2-Methyl-Malonic_Acid
FULL_SYN
  • [18F]-ML-10SYNCI
  • Fluorine F18-2-(5-Fluoro-Pentyl)-2-Methyl-Malonic-AcidSYNCI
  • ApoSense ML-10FBNCI
  • [18F]-2-(5-Fluoro-Pentyl)-2-Methyl-Malonic-AcidSYNCI
  • Fluorine F 18 ML-10SYNCI
  • Fluorine F-18 ML-10PTNCI
DEFINITION
  • A small molecular-weight, malonic acid-based probe [(2-(5-fluoro-pentyl)-2-methyl-malonic acid or ML-10] labeled with the radioactive isotope fluorine F 18 with potential apoptosis radioimaging use. Upon administration, [F18]-ML-10 binds selectively to apoptotic cells due to apoptotic cell membrane features that differ from those of normal, healthy and necrotic cell membranes. Upon entering the apoptotic cell, this agent accumulates within the cytoplasm where it can be imaged using positron emission tomography (PET). Detection of apoptotic cells using this imaging technology may be useful in monitoring tumor responses to cytotoxic therapies. ML-10 appears to mimic the alkyl-malonic acid motif present in gamma -carboxyglutamic (Gla), an amino acid that plays a crucial role in the binding of clotting factors to negatively-charged phospholipids exposed on the surfaces of apoptotic cells.NCI
code
  • C78468
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