About: Transferrin Receptor-Targeted Anti-RRM2 siRNA CALAA-01

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About: Transferrin Receptor-Targeted Anti-RRM2 siRNA CALAA-01 Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	Class
rdfs:label	Transferrin Receptor-Targeted Anti-RRM2 siRNA CALAA-01
rdfs:subClassOf	ANTINEOPLASTICS
Semantic_Type	Pharmacologic Substance
Preferred_Name	Transferrin Receptor-Targeted Anti-RRM2 siRNA CALAA-01
NCI_META_CUI	CL387587
PDQ_Open_Trial_Search_ID	599463
PDQ_Closed_Trial_Search_ID	599463
Legacy_Concept_Name	Transferrin_Receptor-Targeted_Nanocomplexed_Anti-R2_siRNA_CALAA-01
FULL_SYN	Transferrin Receptor-Targeted Anti-RRM2 siRNA CALAA-01PTNCI CALAA-01CNNCI
DEFINITION	A proprietary transferrin receptor-targeted nanoparticle preparation of a non-chemically modified small-interfering RNA (siRNA) directed against the M2 subunit of ribonucleotide reductase (RRM2) with potential antineoplastic activity. Upon administration, transferrin receptor-targeted anti-RRM2 siRNA CALAA-01 binds to transferrin receptors (TfRs), releasing anti-RRM2 siRNA after endocytosis; anti-RRM2 siRNA silences the expression of RRM2 via the RNAi pathway, impeding the assembly of the holoenzyme ribonucleotide reductase (RR) which catalyzes the production of deoxyribonucleotides. As a result, inhibition of cellular proliferation may occur in cells expressing TfR, a cell surface protein overexpressed on various cancer cell types.NCI
code	C78450

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