About: Regorafenib     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Regorafenib
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Regorafenib
UMLS_CUI
  • C2703114
CAS_Registry
  • 755037-03-7
FDA_UNII_Code
  • 24T2A1DOYB
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 595192
PDQ_Closed_Trial_Search_ID
  • 595192
Chemical_Formula
  • C21H15ClF4N4O3
Legacy_Concept_Name
  • Multitargeted_Receptor_Tyrosine_Kinase_Inhibitor_BAY_73-4506
FULL_SYN
  • RegorafenibPTNCI
  • 4-(4-(((4-chloro-3-(trifluoromethyl)phenyl)carbamoyl)amino)-3-fluorophenoxy)-N-methylpyridine-2-carboxamideSNNCI
  • StivargaBRNCI
  • REGORAFENIBPTFDA24T2A1DOYB
  • BAY 73-4506ABNCI
DEFINITION
  • An orally bioavailable small molecule with potential antiangiogenic and antineoplastic activities. Regorafenib binds to and inhibits vascular endothelial growth factor receptors (VEGFRs) 2 and 3, and Ret, Kit, PDGFR and Raf kinases, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation. VEGFRs are receptor tyrosine kinases that play important roles in tumor angiogenesis; the receptor tyrosine kinases RET, KIT, and PDGFR, and the serine/threonine-specific Raf kinase are involved in tumor cell signaling.NCI
code
  • C78204
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