About: Calaspargase Pegol     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Calaspargase Pegol
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Calaspargase Pegol
NCI_META_CUI
  • CL383591
CAS_Registry
  • 941577-06-6
ALT_DEFINITION
  • A drug used to treat acute lymphoblastic leukemia (ALL). It is a form of the anticancer drug PEG-asparaginase that stays in the body longer. EZN-2285 is an enzyme that breaks down the amino acid asparagine and may block the growth of tumor cells that need asparagine to grow. It is a type of protein synthesis inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 595298
PDQ_Closed_Trial_Search_ID
  • 595298
Legacy_Concept_Name
  • Succinimidyl_Carbonate_Monomethoxypolyethylene_Glycol_E_Coli_L-Asparaginase
FULL_SYN
  • Oncaspar-IVBRNCI
  • Oncaspar-IVPTNCI-GLOSSCDR0000637712
  • SC-PEG E. Coli L-AsparaginaseSYNCI
  • SC-PEG E. coli L-asparaginasePTNCI-GLOSSCDR0000637713
  • EZN-2285PTNCI-GLOSSCDR0000637711
  • Calaspargase PegolPTNCI
  • EZN-2285CNNCI
  • Succinimidyl Carbonate Monomethoxypolyethylene Glycol E. coli L-AsparaginaseSYNCI
DEFINITION
  • An intravenous formulation containing E.coli-derived L-asparaginase II conjugated with succinimidyl carbonate monomethoxypolyethylene glycol (SC-PEG), with potential antineoplastic activity. L-asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia, thereby depleting cells of asparagine; asparagine depletion blocks protein synthesis and tumor cell proliferation, especially in the G1 phase of the cell cycle and ultimately induces tumor cell death. Asparagine is critical to protein synthesis in acute lymphoblastic leukemia (ALL) cells which, unlike normal cells, cannot synthesize this amino acid due to the absence of the enzyme asparagine synthase. Pegylation decreases enzyme antigenicity and increases its half life. SC is used as a PEG linker to facilitate attachment to asparaginase and enhances the stability of the formulation.NCI
code
  • C78198
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