About: Docetaxel Emulsion ANX-514

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Attributes	Values
rdf:type	Class
rdfs:label	Docetaxel Emulsion ANX-514
rdfs:subClassOf	Taxane-Pocket Binding Agent
Semantic_Type	Pharmacologic Substance
Preferred_Name	Docetaxel Emulsion ANX-514
NCI_META_CUI	CL383589
PDQ_Open_Trial_Search_ID	595290
PDQ_Closed_Trial_Search_ID	595290
Legacy_Concept_Name	Docetaxel_Emulsion_ANX-514
FULL_SYN	Docetaxel Emulsion ANX-514PTNCI ANX-514CNNCI
DEFINITION	An injectable emulsion formulation containing the taxane docetaxel, a semisynthetic analogue of paclitaxel, with antineoplastic activity. Docetaxel binds specifically to the beta-tubulin subunit of the microtubule, stabilizing tubulin and inhibiting microtubule disassembly, which results in cell-cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and induces various mediators of the inflammatory response. Docetaxel emulsion ANX-514 is formulated without polysorbate 80 or other detergents in order to reduce the incidence and severity of hypersensitivity reactions. In addition, the exclusion of polysorbate 80 in this formulation precludes foaming during the preparation process, thus facilitating preparation and administration.NCI
code	C78196

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