About: Ribosome-Inactivating Protein CY503     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Ribosome-Inactivating Protein CY503
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Ribosome-Inactivating Protein CY503
NCI_META_CUI
  • CL383580
PDQ_Open_Trial_Search_ID
  • 594770
PDQ_Closed_Trial_Search_ID
  • 594770
Legacy_Concept_Name
  • Ribosome-Inactivating_Protein_CY503
FULL_SYN
  • Ribosome-Inactivating Protein CY503PTNCI
DEFINITION
  • A recombinant protein that inactivates the ribosome with potential antineoplastic and immunomodulating activities. Ribosome-inactivating protein CY503 binds to the cell surface sialyltransferase CD75 and is internalized; intracellularly, CY503 cleaves an adenine-specific N-glycosidic bond on the 28S ribosomal subunit, which may result in tumor cell apoptosis. This agent has also been shown to activate natural killer (NK) cells, induce cytokine receptor expression, and stimulate the release of cytokines. CD75 is expressed on mature B-cells and subsets of T-cells and erythrocytes.NCI
code
  • C78188
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