About: Methoxyamine Hydrochloride     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Methoxyamine Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Methoxyamine Hydrochloride
NSC_Code
  • 3801
UMLS_CUI
  • C0951345
CAS_Registry
  • 593-56-6
FDA_UNII_Code
  • 203546OLMF
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of cancer. It blocks the ability of a cell to repair damage to its DNA and may kill cancer cells. It may also help some anticancer drugs work better. It is a type of antineoplastic agent.NCI-GLOSS
Chemical_Formula
  • CH5NO.HCl
Legacy_Concept_Name
  • Methoxyamine_Hydrochloride
FULL_SYN
  • Methoxyamine HydrochloridePTNCI
  • methoxyamine hydrochloridePTNCI-GLOSSCDR0000648993
  • METHOXYAMINE HYDROCHLORIDEPTFDA203546OLMF
DEFINITION
  • The hydrochloride salt form of methoxyamine, an alkoxyamine with potential chemotherapeutic adjuvant activity. Methoxyamine covalently binds to apurinic/apyrimidinic DNA damage sites and thereby inhibits base excision repair (BER) process, which may prevent repair of DNA strand breaks and result in an induction of apoptosis. This agent may potentiate the anti-tumor activity of alkylating agents.NCI
code
  • C78085
is Has_Salt_Form of
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