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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Methoxyamine
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Methoxyamine
UMLS_CUI
  • C0066156
CAS_Registry
  • 67-62-9
FDA_UNII_Code
  • 9TZH4WY30J
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 599836
PDQ_Closed_Trial_Search_ID
  • 599836
Chemical_Formula
  • CH5NO
Legacy_Concept_Name
  • Methoxyamine
FULL_SYN
  • METHOXYAMINEPTFDA9TZH4WY30J
  • MethoxyaminePTNCI
  • TRC102CNNCI
DEFINITION
  • An orally bioavailable small molecule inhibitor with potential adjuvant activity. Methoxyamine covalently binds to apurinic/apyrimidinic (AP) DNA damage sites and inhibits base excision repair (BER), which may result in an increase in DNA strand breaks and apoptosis. This agent may potentiate the anti-tumor activity of alkylating agents.NCI
code
  • C78084
is Has_Free_Acid_Or_Base_Form of
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