About: Immunotherapy Regimen MKC-1106-MT     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Immunotherapy Regimen MKC-1106-MT
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Immunotherapy Regimen MKC-1106-MT
NCI_META_CUI
  • CL386958
PDQ_Open_Trial_Search_ID
  • 598417
PDQ_Closed_Trial_Search_ID
  • 598417
Legacy_Concept_Name
  • MKC-1106-MT
FULL_SYN
  • Immunotherapy Regimen MKC-1106-MTPTNCI
  • MKC-1106-MTSYNCI
DEFINITION
  • An immunotherapy regimen containing three components: a plasmid encoding portions of the two melanoma-associated antigens Melan A (also called MART-1) and tyrosinase and two synthetic analogs of Melan-A and tyrosinase antigen epitopes with potential immunostimulating and antitumor activities. First, the plasmid is injected directly into lymph nodes in order to sensitize or prime antigen-presenting cells (APCs) and central memory T cells in lymph nodes to plasmid-expressed Melan A and tyrosinase. After several priming injections with plasmids, the Melan A and tyrosinase synthetic epitope analogs are injected directly into lymph nodes; upon binding to major histocompatibility complex (MHC) molecules on APC cell surfaces, these synthetic epitope analogs may stimulate a "primed" cytotoxic T lymphocyte (CTL) response against melanoma tumor cells, resulting in tumor cell lysis. Melan-A and tyrosinase are overexpressed by melanoma tumor cells.NCI
code
  • C77971
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