About: NAE Inhibitor MLN4924     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • NAE Inhibitor MLN4924
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • NAE Inhibitor MLN4924
UMLS_CUI
  • C2720164
PDQ_Open_Trial_Search_ID
  • 596795
PDQ_Closed_Trial_Search_ID
  • 596795
Legacy_Concept_Name
  • NAE_Inhibitor_MLN4924
FULL_SYN
  • MLN4924CNNCI
  • Nedd8-Activating Enzyme Inhibitor MLN4924SYNCI
  • NAE Inhibitor MLN4924PTNCI
DEFINITION
  • A small molecule inhibitor of Nedd8 activating enzyme (NAE) with potential antineoplastic activity. NAE inhibitor MLN4924 binds to and inhibits NAE, which may result in the inhibition of tumor cell proliferation and survival. NAE activates Nedd8 (Neural precursor cell expressed, developmentally down-regulated 8), an ubiquitin-like (UBL) protein that modifies cellular targets in a pathway that is parallel to but distinct from the ubiquitin-proteasome pathway (UPP). Functioning in diverse regulatory activities, proteins conjugated to UBLs like Nedd8 typically are not targeted for proteasomal degradation.NCI
code
  • C77906
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