About: Glycosylated Recombinant Human Interleukin-7     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Glycosylated Recombinant Human Interleukin-7
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Glycosylated Recombinant Human Interleukin-7
NCI_META_CUI
  • CL387271
PDQ_Open_Trial_Search_ID
  • 597722
PDQ_Closed_Trial_Search_ID
  • 597722
Legacy_Concept_Name
  • Glycosylated_Recombinant_Human_Interleukin-7
FULL_SYN
  • Glycosylated Recombinant Human Interleukin-7PTNCI
  • CYT107CNNCI
  • Glycosylated rhIL-7ABNCI
DEFINITION
  • A glycosylated recombinant protein which is chemically identical to or similar to endogenous human interleukin-7 (IL-7) with hematopoietic and immunopotentiating activities. Naturally produced by bone marrow, thymic stromal, and spleen cells, the cytokine interleukin-7 is a hematopoietic growth factor for progenitor B cells and T cells, stimulating proliferation and differentiation of mature T-cells and natural killer (NK) cells. As with glycosylated endogenous proteins, glycosylation of recombinant proteins may fundamentally affect their biological activity, function, clearance from circulation, and antigenicity; glycosylation of recombinant proteins that are chemically idenitical to or similar to endogenous proteins may render protein structures and biological activities that are more similar to those of glycosylated endogenous proteins.NCI
code
  • C77879
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