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AttributesValues
rdf:type
rdfs:label
  • Tyroserleutide
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Tyroserleutide
UMLS_CUI
  • C1451018
PDQ_Open_Trial_Search_ID
  • 593430
PDQ_Closed_Trial_Search_ID
  • 593430
Legacy_Concept_Name
  • Tyroserleutide
FULL_SYN
  • TyroserleutidePTNCI
  • YSLABNCI
  • CMS 024CNNCI
DEFINITION
  • A tripeptide consisting of tyrosine, serine, and leucine with potential antineoplastic activity. Although the mechanism of its antitumor activity has yet to be fully elucidated, tyroserleutide appears to inhibit the expression of ICAM-1 (CD54), a cell adhesion factor of the immunoglobulin (Ig) superfamily that plays an important role in the invasion, adhesion, and metastasis of tumor cells. In addition, this agent may influence the Ca2+/calmodulin pathway, inhibiting phosphatidylinositol 3 kinase (PI3K); PI3K is upregulated in tumor cells and is involved in cellular proliferation.NCI
code
  • C77856
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