About: Enteric-Coated Zoledronic Acid Tablet MER-101     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Enteric-Coated Zoledronic Acid Tablet MER-101
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
  • Organophosphorus Compound
Preferred_Name
  • Enteric-Coated Zoledronic Acid Tablet MER-101
NCI_META_CUI
  • CL383558
PDQ_Open_Trial_Search_ID
  • 592901
PDQ_Closed_Trial_Search_ID
  • 592901
Legacy_Concept_Name
  • Oral_Zoledronic_Acid
FULL_SYN
  • Zoledronic Acid TabletSYNCI
  • Enteric-Coated Zoledronic Acid Tablet MER-101PTNCI
  • MER-101CNNCI
DEFINITION
  • An oral tablet formulation containing zoledronic acid combined with a proprietary absorption enhancer for improved zoledronic acid gastrointestinal absorption with anti-bone-resorption activity. The third-generation bisphosphonate zoledronic acid binds to hydroxyapatite crystals in the bone matrix, slowing their dissolution and inhibiting the formation and aggregation of these crystals. This agent also inhibits farnesyl pyrophosphate synthase, an enzyme involved in terpenoid biosynthesis. Inhibition of this enzyme prevents the biosynthesis of isoprenoid lipids, donor substrates of farnesylation and geranylgeranylation during the post-translational modification of small GTPase signalling proteins, which are important in the process of osteoclast turnover. The proprietary absorption enhancer is a GRAS (generally-recognized-as-safe) food additive.NCI
code
  • C77855
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