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AttributesValues
rdf:type
rdfs:label
  • Ketotrexate
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Ketotrexate
UMLS_CUI
  • C2697842
CAS_Registry
  • 877017-93-1
FDA_UNII_Code
  • 504RN634MM
Contributing_Source
  • FDA
Chemical_Formula
  • C21H27N7O6
Legacy_Concept_Name
  • Ketotrexate
FULL_SYN
  • KetotrexatePTNCI
  • KETOTREXATEPTFDA504RN634MM
DEFINITION
  • A folic acid antagonist and mammalian dihydrofolate reductase inhibitor with antineoplastic activity. Ketotrexate inhibits dihydrofolate reductase, an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid which is essential for the synthesis of purine nucleotides and thymidylate. By depleting tetrahydrofolic acid availability, DNA synthesis is halted.NCI
code
  • C77403
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