About: Atiprimod Dihydrochloride     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Atiprimod Dihydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Atiprimod Dihydrochloride
UMLS_CUI
  • C2698190
CAS_Registry
  • 130065-61-1
FDA_UNII_Code
  • O12I24570R
Contributing_Source
  • FDA
Chemical_Formula
  • C22H44N2.2ClH
Legacy_Concept_Name
  • Atiprimod_Dihydrochloride
FULL_SYN
  • Atiprimod DihydrochloridePTNCI
  • ATIPRIMOD DIHYDROCHLORIDEPTFDAO12I24570R
DEFINITION
  • The dihydrochloride salt form of atiprimod, an orally bioavailable small molecule belonging to the azaspirane class of cationic amphiphilic agents with anti-inflammatory, antineoplastic, and anti-angiogenic activities. Atiprimod inhibits the phosphorylation of signal transducer and activator of transcription 3 (STAT3) and AKT, blocking the signaling pathways of interleukin-6, vascular endothelial growth factor (VEGF) and downregulating the anti-apoptotic proteins Bcl-2, Bcl-XL, and Mcl-1. This results in the inhibition of cell proliferation, induction of cell cycle arrest, and apoptosis.NCI
code
  • C76969
is Has_Salt_Form of
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