About: Lisdexamfetamine Dimesylate     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Lisdexamfetamine Dimesylate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Lisdexamfetamine Dimesylate
UMLS_CUI
  • C1739826
CAS_Registry
  • 608137-33-3
FDA_UNII_Code
  • SJT761GEGS
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 663453
PDQ_Closed_Trial_Search_ID
  • 663453
Chemical_Formula
  • C15H25N3O.2CH4O3S
Legacy_Concept_Name
  • Lisdexamfetamine_Dimesylate
FULL_SYN
  • Lisdexamfetamine DimesylatePTNCI
  • VyvanseBRNCI
  • LISDEXAMFETAMINE DIMESYLATEPTFDASJT761GEGS
DEFINITION
  • The dimesylate form and prodrug of the d-isomer of amphetamine, a non-catecholamine sympathomimetic amine with central nervous system (CNS) stimulating activity. Upon administration, lisdexamphetamine is converted to dextroamphetamine through cleavage of the lysine group. Dextroamphetamine acts by facilitating the release of catecholamines, particularly noradrenaline and dopamine, from its storage sites in nerve terminals in the CNS, and inhibits their uptake within the mesocorticolimbic system, a major component of the brain reward system, resulting in measurable behavioral changes such as euphoria, mental alertness and excitement and appetite suppression. As a CNS stimulant, this agent may increase blood pressure.NCI
code
  • C76628
is Has_Salt_Form of
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