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AttributesValues
rdf:type
rdfs:label
  • Golotimod
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Golotimod
UMLS_CUI
  • C1173246
CAS_Registry
  • 229305-39-9
FDA_UNII_Code
  • 637C487Y09
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 617379
PDQ_Closed_Trial_Search_ID
  • 617379
Chemical_Formula
  • C16H19N3O5
Legacy_Concept_Name
  • Golotimod
FULL_SYN
  • (2R)-2-Amino-5-(((1S)-1-carboxy-2-(1H-indol-3-yl)ethyl)amino)-5-oxopentanoic AcidSNNCI
  • SCV07CNNCI
  • gamma-D-Glu-L-trpABNCI
  • SCV 07CNNCI
  • SCV-07CNNCI
  • GOLOTIMODPTFDA637C487Y09
  • Gamma-D-Glutamyl-L-TryptophanSYNCI
  • GolotimodPTNCI
DEFINITION
  • An orally bioavailable synthetic peptide containing the amino acids D-glutamine and L-tryptophan connected by a gamma-glutamyl linkage with potential immunostimulating, antimicrobial and antineoplastic activities. Although the exact mechanism of action is unknown, golotimod appears to inhibit the expression of STAT-3, reversing immunosuppression and stimulating an anti-tumor immune response. This agent may stimulate the production of T-lymphocytes, in particular the helper T (Th1) cells, activate macrophages, and increase levels of interleukin 2 and interferon gamma. STAT-3, a transcription factor upregulated in many cancer cell types, is involved in tumor cell growth and survival and immunosuppression.NCI
code
  • C76497
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