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AttributesValues
rdf:type
rdfs:label
  • Cefazedone
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Cefazedone
UMLS_CUI
  • C0054999
CAS_Registry
  • 56187-47-4
FDA_UNII_Code
  • 7Y86X0D799
Contributing_Source
  • FDA
Chemical_Formula
  • C18H15Cl2N5O5S3
Legacy_Concept_Name
  • Cefazedone
FULL_SYN
  • (6R,7R)-7-(2-(3,5-Dichloro-4-oxo-1(4H)-pyridyl)acetamido)-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)-oct-2-ene-2-carboxylic AcidSNNCI
  • CEFAZEDONEPTFDA7Y86X0D799
  • CefazedonePTNCI
DEFINITION
  • A semisynthetic first-generation cephalosporin with antibacterial activity. Cefazedone binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.NCI
code
  • C76157
is Has_Free_Acid_Or_Base_Form of
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