About: Cefluprenam     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Cefluprenam
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Cefluprenam
UMLS_CUI
  • C0652447
CAS_Registry
  • 116853-25-9
FDA_UNII_Code
  • 098633Q42P
Contributing_Source
  • FDA
Chemical_Formula
  • C20H25FN8O6S2
Legacy_Concept_Name
  • Cefluprenam
FULL_SYN
  • CefluprenamPTNCI
  • CEFLUPRENAMPTFDA098633Q42P
DEFINITION
  • A semisynthetic, broad-spectrum, fourth-generation cephalosporin with antibacterial activity. Cefluprenam binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.NCI
code
  • C76034
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