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AttributesValues
rdf:type
rdfs:label
  • Dasatinib Anhydrous
rdfs:subClassOf
Has_Target
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Dasatinib Anhydrous
UMLS_CUI
  • C2699562
CAS_Registry
  • 302962-49-8
FDA_UNII_Code
  • X78UG0A0RN
Contributing_Source
  • FDA
Chemical_Formula
  • C22H26ClN7O2S
Legacy_Concept_Name
  • Dasatinib_Anhydrous
CHEBI_ID
  • CHEBI:49375
FULL_SYN
  • Dasatinib AnhydrousPTNCI
  • DASATINIB ANHYDROUSPTFDAX78UG0A0RN
DEFINITION
  • An orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity for the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations. SRC-family protein-tyrosine kinases interact with variety of cell-surface receptors and participate in intracellular signal transduction pathways; tumorigenic forms can occur through altered regulation or expression of the endogenous protein and by way of virally-encoded kinase genes.NCI
code
  • C74556
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